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Cyclopropylmethyl bromide is an intermediate Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670) Firocoxib (ML 1785713) is a potent selective orally active COX-2 inhibitor[1]
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Sulfadiazine (CAS 68-35-9) is a small-molecule inhibitor targeting dihydropteroate synthase It is designed to inhibit microbial folate biosynthesis thereby disrupting folic acid synthesis required for pathogen proliferation Sulfadiazine exerts its biological activity primarily through the competitive inhibition of dihydropteroate synthase In in vitro studies Sulfadiazine demonstrates antiparasitic activity with IC50 values ranging from approximately 2 g/mL to 5 g/mL against Toxoplasma gondii depending on experimental conditions and parasite strains Based on these pharmacological properties Sulfadiazine holds research potential in antiparasitic activity evaluation and studies of folic acid metabolism pathways
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Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
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Chemical. CAS 344458-15-7. Formula C17H17N3O2 . HCl. MW 295.2 . 36.5. Potent, water soluble polyADP-ribose polymerase PARP inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells.
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Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
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Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
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Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
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Sodium Sulfadiazine (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine an intermediate-acting bacteriostatic synthetic sulfanilamide derivative
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